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Sertima (Sertraline) is a selective serotonin reuptake inhibitor which is used to control major depressive disorder in adults. It is believed to work by affecting natural chemicals and neurotransmitters in the brain Uses of Generic Zoloft (Sertima Tablets by Intas) This antidepressant is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).