Avana containing the active ingredient avanafil is a PDE5 inhibitor (phosphodiesterase type 5 inhibitor) type of medication. It increases blood flow to certain parts of the body by relaxing the muscles. It blocks PDE5 in smooth muscle cells lining the blood vessels supplying corpus cavernosum to the penis. The medication is commonly used to treat erectile dysfunction. It is usually a faster acting medication that also passes through the body at a quicker rate than most erectile dysfunction drugs.